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Actively Enrolling

Diabetic Macular Edema

• DIAMOND-2: WC

  Oculis – DX 221

  A Phase 3, Double-Masked, Randomized, Multicenter Study of the Efficacy and Safety of OCS 01 Eye Drops in Subjects with Diabetic Macular Edema

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• BRUNELLO: WC

  Eyebiotech, Ltd EYE-RES-102

  EYE-RES-102 is a randomized, double masked pivotal study to evaluate the efficacy and safety of 2 dose levels of EYE103 in comparison with the active control, ranibizumab, in patients with diabetic macular edema (DME)

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Intermediate Age-Related Macular Degeneration (iAMD)

• HONU: Florence

  Genentech – GE43220

  A Multicenter, Prospective, Observational Study of the Progression of Intermediate Age-Related Macular Degeneration

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Macular Telangiectasia

• NHOR – WC

  The Lowy Medical Research Institute – NHOR

  A Natural History Observation and Registry Study of Macular Telangiectasia Type-2

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Wet AMD

• NORSE 8: West Columbia & Florence

  Outlook Therapeutics – ONS-5010

  A Phase 3, 3-Month Study to Assess the Safety and Effectiveness of ONS-5010 Compared to Lucentis in Subjects with Neovascular Age-related Macular Degeneration: NORSE EIGHT

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• SOLEIL/SOL1: West Columbia, Florence & Aiken

  Ocular Therapeutix – OTX-TKI-2023-AMD-301

  Phase 3 Study to Evaluate the Efficacy and Safety of Intravitreal OTX-TKI (axitinib implant) in Subjects with Neovascular Age-Related Macular Degeneration: SOLEIL/SOL 1

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• SOL-R: WC

  Ocular Therapeutix – OTX-TKI-2023-AMD-303

  A Phase 1/2 Dose-Escalation and Randomized, Controlled, Masked Expansion Trial in Adults with wet AMD Undergoing Active Anti-VEGF Treatment

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• 4DMT PRISM: West Columbia

  4D Molecular Therapy – 4D-150

  A Phase 1/2 Dose-Escalation and Randomized, Controlled, Masked Expansion Trial in Adults with wet AMD Undergoing Active Anti-VEGF Treatment

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• THEIA: WC

  Kalaris Therapeutics, Inc KLRS-100

  A Phase 1 Open-label Clinical Trial to Establish the Safety, Tolerability, Dose-Range and Pharmacokinetic Profile of Intravitreal Injection of TH103 in Patients with Neovascular Age Related Macular Degeneration

  N/A – link currently unavailable.

DME & Wet AMD

• ELARA: WC

  Regeneron VGFTe-HD-OD-2444

  A Phase 3B Single-Arm Study of Aflibercept 8 mg in Participants with Neovascular Age-Related Macular Degeneration (nAMD) or Diabetic Macular Edema (DME)

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Contact Information

If you are interested in learning more about these clinical trials, please contact our offices at (803) 931-0077